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KMID : 0043320110340122043
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Archives of Pharmacal Research
2011 Volume.34 No. 12 p.2043 ~ p.2049
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A new lignan glycoside from Juniperus rigida
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Woo Kyeong-Wan
Choi Sang-Un
Park Jong-Cheol
Lee Kang-Ro
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Abstract
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A new lignan glycoside, named juniperigiside (1) was isolated from the CHCl3 soluble fraction of the MeOH extract of stems and leaves of Juniperus rigida S.et Z. Compound 1 was identified by 1D- and 2D-NMR spectroscopy as well as CD analysis as (2R,3S)-2,3-dihydro-7-methoxy-2-(4′-hydroxy-3′-methoxyphenyl)-3-hydroxymethyl-5-benzofuranpropanol 4′-O-(3-O-methyl)-α-L-rhamnopyranoside. Five known lignans, icariside E4 (2), desoxypodophyllotoxin (3), savinin (4), thujastandin (5), and (?)-nortrachelogenin (6) in addition to five known labdane diterpenes including trans-communic acid (7), 13-epi-torulosal (8), 13-epi-cupressic acid (9), imbricatoric acid (10), and isocupressic acid (11) were also isolated and their structures were characterized by comparing their spectroscopic data with those in the literature. All compounds were isolated for the first time from this plant, and 5 and 6 were first reported from the genus Juniperus. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay. Compounds 3, 4, 7, and 8 showed considerable cytotoxicity against four human cancer cell lines in vitro.
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KEYWORD
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Juniperus rigida, Cupressaceae, Lignan glycoside, Labdane diterpene, Cytotoxicity
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